UPC: 9781588291998 | Molecular Neurosurgery with Targeted Toxins (Hardcover)
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UPC lookup results for: 9781588291998 | Molecular Neurosurgery with Targeted Toxins (Hardcover)
Pioneers and leading researchers explain the theory and techniques of using targeted toxins experimentally. The highly successful use of the 192 IgG-saporin and ME20.4-saporin immunotoxins to lesion the cholinergic basal forebrain in order to model the behavior anatomy physiology and pharmacology of Alzheimer s disease in animals is treated in detail too give a potential user the knowledge to comfortably use the techniques involved. The uses of important new lesioning agents such as anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons hypocretin-saporin that can produce narcoleptic animals and other saporin conjugates such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of CNS demyelination are explained by experts in the field.
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